陈蕾

日期: 2023/09/11 作者: 浏览量:




陈蕾,博士,教授,博士生导师。近年来共主持省部级以上项目10余项,第一或通讯作者发表SCI文章20余篇,制订山东省地方标准5项,授权发明专利4件。获得齐鲁最美青年齐鲁最美职工和山东战最美青年称号。

邮箱:chenlei@sdnu.edu.cn

一、研究方向:病原检测与免疫分子机制

二、主持项目:

    1. 国家重点研发计划子课题 复杂生物体系代谢组的高通量超灵敏定性定量分析技术研究 2022-2027

    2. 高端外国专家引进计划 微流控芯片技术在病原检测中的应用 2022-2024

    3. 国家自然科学基金:FMDV 3C蛋白抑制IIIFN信号通路的机制研究, 316020892017.01-2019.12

    4.  2022年度山东省重点扶持区域引进急需紧缺人才项目:糖胺聚糖药物的关键共性技术研发及产业化,2022.09--2023.8

    5. 山东省重大农业应用创新:规模化猪场主要疫病免疫监测与防控技术集成,2017.05--2019.04

    6. 山东省重大农业应用创新:影响动物卫生安全的重大动物疫病及人畜共患病综合控制技术研究、集成和应用子课   题,2019.3-2021.2

    7. 山东省高等学校青年创新团队发展计划:水生生物免疫研究创新团队,2019.11-2021.10

    8. 山东省重点研发计划(软科学项目)重大项目:山东省创新药物与高端医疗器械技术创新现状分析与对策研究,2020.1-2020.12

    9. 山东省新型冠状病毒感染的肺炎疫情应急技术攻关及集成应用重大科技创新工程:新型冠状病毒感染的快速多重诊断检测技术和装备的研发与应用子课题,2020.2

三、代表性成果

    1.第一/通讯作者论文

 (1) Hua Wang, Yang Sun, Yuan Zhou, Yujie Liu, Shuo Chen, Wenbo Sun, Zidong Zhang, Junqing Guo, Cheng Yang, Zhengping Li, Lei Chen*. Unamplified system for sensitive and typing detection of ASFV by the cascade platform that CRISPR-Cas12a combined with graphene field-effect transistor. Biosens Bioelectron. 2023 Aug 25;240:115637. doi: 10.1016/j.bios.2023.115637. IF=12.545

(2) Y. Sun, C. Yang, X. Jiang, P. Zhang, S. Chen, F. Su, H. Wang, W. Liu, X. He, L. Chen*, B. Man*, Z. Li*, High-intensity vector signals for detecting SARS-CoV-2 RNA using CRISPR/Cas13a couple with stabilized graphene field-effect transistor, Biosens Bioelectron, 222 (2023) 114979. IF= 12.545

(3) Yujie Liu, Hui Liu, Guanliu Yu, Wenbo Sun, Muhammad Aizaz, Guiwen Yang, Lei Chen*, One-tube RPA-CRISPR Cas12a/Cas13a rapid detection of methicillin-resistant Staphylococcus aureus, Analytica Chimica Acta, ISSN 0003-2670,https://doi.org/10.1016/j.aca.2023.341757. IF=6.2

(4) Linyi Bai, Guanliu Yu, Yujie Liu, Muhammad Aizaz, Guiwen Yang, Lei Chen*. Common carp intelectin 3 (cITLN3) plays a role in the innate immune response. Fish & shellfish immunology. https://doi.org/10.1016/j.fsi.2023.109057. IF=4.622

(5) Xiangju Wua1, Lei Chen 1, Chao Sui, Yue Hu, Dandan Jiang, Fan Yang, Laura C. Miller, Juntong Li, Xiaoyan Cong, Nataliia Hrabchenko , Changhee Lee e, Yijun Du, Jing Qi*, 3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation, Virologica Sinica 38 (2023) 387–397. IF=5.5

(6) Linyi Bai, Hao Zhang, Yuan Zhou, Hongkun Liang, Shujun Chen, Xuehui Pang, G Mauk Michael, Lulu Zhang, Lei Chen*. Development of a surface plasmon resonance (SPR) assay for rapid detection of Aeromonas hydrophila. Analytical Biochemistry. 2023 Jun 1;670:115151. doi: 10.1016/j.ab.2023.115151. IF=3.365

(7) Linyi Bai, Yuan Zhou, Chen Sheng, Yizhi Yin, Yanru Chen, Xinli Ding, Guanliu Yu, Guiwen Yang, Lei Chen*. Common carp Peptidoglycan Recognition Protein 2 (CcPGRP2) plays a role in innate immunity for defense against bacterial infections, Fish & shellfish immunology. 2023 Jan 20;133:108564. doi: 10.1016/j.fsi.2023.108564. IF=4.622

(8) Hua Wang, Xinli Ding, Wenbo Sun, Zhi Chen, Linyi Bai, Hongkun Liang, Yujie Liu,Wanli Zhang, Guisheng Wang, Guiwen Yang, Michael G. Mauk, Yuanyuan Cui, Lei Chen*. Recombinase polymerase amplification assay for rapid detection of Seneca Valley VirusAnalytical Biochemistry 642 (2022) 114564. IF=3.365

(9) Jinyi Li, Yanru Chen, Wei Gu, Fojiao Xu, Hua Li, Shijuan Shan, Xiaojie Sun, Miao Yin, Guiwen Yang, Lei Chen* Characterization of a common carp intelectin gene with bacterial binding and agglutination activityFish and Shellfish Immunology 108 (2021) 32–41. IF=3.298

(10) Lei Chen*, Jinyi Li, Guiwen Yang. A comparative review of intelectins. Review Scand J Immunol. 2020 Jul;92(1):e12882.doi: 10.1111/sji.12882.Epub 2020 Apr 14. IF=3.191

2.授权发明专利

(1)孙文博, 吴家强, 陈智, 郑乾坤, 李敏, 邱宪波, 张璐璐, 刘国宪, 杜以军, 丛晓燕, 陈蕾, 于江, 李俊, 时建立, 郭立辉, 任素芳,猪内脏组织活体采样并进行核酸提取的装置,ZL201811145454.2

(2) 杜以军,王金宝,丛晓燕,陈蕾,齐静,孙文博,吴家强,陈智,于江,郭立辉,任素芳,表达猪PCD163的细胞系、其制备方法及应用,2017.7.28-2037.1.26中国,ZL201510027577.6

(3) 杜以军,齐静,王金宝,吴家强,黄保华,郭立辉,陈蕾,丛晓燕,孙文博,任素芳,李俊,时建立,吕伟,高效表达的猪粒细胞巨噬细胞集落刺激因子基因及其表达蛋白的用途,2013.7.10-2033.4.8,中国,CN201310119033.3

(4) 孙国庆,李志清,陈蕾,凌晓光,四氢嘧啶合成酶基因、重组载体、重组工程菌及其应用,2012.6.27-2031.12.16,中国,CN201110420743.0

3.山东省地方标准

(1) 猪附红细胞体PCR检测技术,DB 37/T 3086—2017

(2) 猪伪狂犬病毒野毒PCR检测技术,DB 37/T 3087—2017

(3) 高致病性猪繁殖与呼吸综合征病毒株和经典毒株的RT-PCR鉴别检测技术DB 37/T 3085-2017

(4) 小反刍兽疫恒温扩增检测技术规范,DB37T4052-2020

(5) 非洲猪瘟恒温扩增检测技术规范,DB37T4032-2020